| Date |
Morning |
Afternoon |
| Day
1 |
| |
Synthetic
Route Discovery |
 |
Introduction-the
purpose of chemical development. |
|
|
Discovering
the best synthetic route. |
|
|
Selecting
the best route for scale-up. |
|
|
Choice of
raw materials, reagents etc. |
|
|
Problem classes
and case studies. |
|
| |
Chemical
Development & Optimization |
|
The investigative
approach to chemical development |
|
|
Effect of
process variables on yield and quality of products. |
|
|
Quality control
in process analysis as an aid to optimization. |
| |
Quality
control in process analysis as an aid to optimization. |
| |
|
|
| Day
2 |
| |
Chemical
Development & Optimization |
|
Designing
a robust process and preventing scale-up problems. |
|
|
Solvent effects. |
|
|
Work up and
product isolation. |
| |
|
| |
|
|
| |
Statistical
Methods of Optimization |
|
Selecting
the parameters to vary. |
|
|
Factorial
designs. Simplex and evolutionary operation. |
|
|
Response surfaces. |
|
|
Case studies. |
| |
|
|
| Day
3 |
| |
Chemical
Engineering Aspects |
|
Appreciation
of chemical engineering concepts, understanding the importance
of heat and mass transfer, mixing, kinetics etc. |
|
|
Thermal hazard
testing and runaway reactions. |
|
|
Planning for
scale-up. |
|
|
Problems and
case studies. |
|
| |
Chemical
Engineering Aspects |
|
Crystallization
and polymorphism.Design of environmentally friendly processes. |
|
|
Effluent minimization
and control. |
|
|
Chemical
development of enantiomerically pure products, resolution,
chiral synthesis etc. |
|
|
Case studies
and problems. |
|
|
Final
overview. |
|
